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Category FAQs Search : Leigh Syndrome (Leigh’s Disease)

Question: What mitochondrial DNA changes cause Leigh syndrome (Leigh’s disease)?

Answer: About 2 in 10 children inherit a change in mitochondrial DNA (mtDNA) from their mothers. Both boys and girls can inherit this gene change, which then can affect every generation of a family. Rarely, a spontaneous mtDNA mutation occurs. The most common mtDNA change in Leigh syndrome keeps the MT-ATP6 gene from making ATP.

(Source: Cleveland Clinic, 21 Nov 2025)

Source Link: https://my.clevelandclinic.org/health/diseases/6037-leigh-syndrome-leighs-disease